Aggrescan3D
Structure-based aggregation profiling with Aggrescan3D
Identify and quantify aggregation-prone regions in structured proteins with atomic precision using Aggrescan3D. This structure-based pipeline projects intrinsic aggregation propensities onto user-defined 3D models, leveraging a refined Aggrescan algorithm to pinpoint solvent-exposed hotspots and guide solubility assessment for therapeutic and biotechnological applications.
Estimated resource cost: 0.000527
Categories: Protein Design
Tags: Aggregation Risk Developability Expression Solubility
Key Capabilities
- Projects aggregation scores onto protein structures using the Aggrescan scale, analyzing residues in user-provided 3D models.
- Uses spherical modeling around carbon-alpha atoms to assess how nearby residues and solvent exposure affect aggregation tendency.
- Identifies aggregation-prone regions by focusing on surface-exposed areas while excluding buried hydrophobic residues.
- Performs better than sequence-based prediction methods when analyzing naturally folded proteins.
Runtime Statistics
| Metric | Value |
|---|---|
| runtime_mean | 13 |
| runtime_median | 7 |
| runtime_std | 15 |
| runtime_90th_percentile | 32 |
| runtime_max | 91 |
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Ready to submit your job?
Review your configuration, then confirm the estimated credit cost before you run the job. Note that credit estimates are not guaranteed and runtime can vary depending on inputs and settings.
Estimated Credits: 0.000527
Invite-only, limited-time access. Please contact ztang@getantibody.com.
Invite-only, limited-time access. Please contact ztang@getantibody.com.