BindCraft
One-shot design of functional protein binders.
BindCraft is a state-of-the-art protein design platform for creating functional binders in a single step. Built on cutting-edge deep learning methods, it predicts high-affinity protein–protein interactions, enabling researchers to design antibodies, nanobodies, peptides, and custom binding partners with precision. BindCraft streamlines the entire process with structural predictions, interface analyses, and downloadable data, making it an essential tool for drug discovery, protein engineering, and synthetic biology.
Estimated resource cost: 0.0007905
Categories: Protein Design
Key Capabilities
- One-shot design of functional protein binders with high accuracy, powered by deep learning models specialized for protein–protein interactions.
- Generates 3D structural predictions for designed binders, including residue-level confidence metrics and binding interface maps.
- Interactive visualization of predicted complexes, with tools for analyzing binding orientation, buried surface area, and solvent accessibility.
- Comprehensive downloads of structures, binding scores, and design inputs for downstream molecular modeling or wet-lab validation.
- Supports binder design against monomeric proteins, multimers, and complex targets such as antibodies, nanobodies, and receptors.
- Flexible input modes: design from sequence, structure, or custom templates to accelerate binder discovery.
- Integrates solvent accessible surface area (SASA) calculations to assess binding energetics and interface quality.
- Optimized pipeline for speed and scalability, enabling both rapid prototyping of candidate binders and high-throughput screening workflows.
- Designed for compatibility with modern protein engineering practices, including affinity maturation and stability optimization.
- Uses a commercial friendly implementation without Rosetta.
Runtime Statistics
| Metric | Value |
|---|---|
| runtime_mean | 22792 |
| runtime_median | 16138 |
| runtime_std | 21497 |
| runtime_90th_percentile | 67563 |
| runtime_max | 91266 |
Similar Tools
- AfCycDesign
- BindFilter
- BioBind
- ProteinMPNN-ddG
Ready to submit your job?
Review your configuration, then confirm the estimated credit cost before you run the job. Note that credit estimates are not guaranteed and runtime can vary depending on inputs and settings.
Estimated Credits: 0.0007905
Invite-only, limited-time access. Please contact ztang@getantibody.com.
Invite-only, limited-time access. Please contact ztang@getantibody.com.