BioFold
Optimize enzyme thermostability, pH stability, solubility, and reaction rate with high accuracy.
The most accurate approach for in silico enzyme optimization. BioFold makes it trivial to optimize multiple enzyme properties, simultaneously.
Estimated resource cost: 0.001178
Categories: Protein Design
Tags: Developability Enzymes Proteins Solubility Stability
Key Capabilities
- Utilizes our proprietary BioFold model to optimize enzymes.
- 40-fold increase in Spearman rank correlation when compared to Meta's ESM-1v model.
- Can optimize the thermostability, pH stability, and reaction rate of a target enzyme.
- Output sequences tend to be evolutionarily distinct and diverse.
- Typical sequence identity to wild type is around 49-56%.
- When tested on β-lactamase, BioFold was found to have a 100% experimental success rate.
- Currently only supports monomeric enzymes that do not form complex interactions with nucleotides.
Runtime Statistics
| Metric | Value |
|---|---|
| runtime_mean | 12833 |
| runtime_median | 8469 |
| runtime_std | 14161 |
| runtime_90th_percentile | 21062 |
| runtime_max | 73247 |
Similar Tools
- BioFold2
- BindFilter
- Efficient Evolution
- EpHod Optimal Enzyme pH Prediction
Ready to submit your job?
Review your configuration, then confirm the estimated credit cost before you run the job. Note that credit estimates are not guaranteed and runtime can vary depending on inputs and settings.
Estimated Credits: 0.001178
Invite-only, limited-time access. Please contact ztang@getantibody.com.
Invite-only, limited-time access. Please contact ztang@getantibody.com.