BoltzGen
Generate high-affinity binders for proteins, nucleic acids, and small molecules using an all-atom diffusion model.
BoltzGen is a universal all-atom generative model for biomolecular binder design. It unifies sequence design and structure prediction within a single diffusion-based framework, enabling the creation of high-affinity binders against proteins, nucleic acids, and small molecules. Through a geometry-based representation and a flexible design specification language, BoltzGen allows precise control over covalent bonds, structural motifs, and binding interfaces while maintaining state-of-the-art folding accuracy.
Estimated resource cost: 0.001178
Categories: Protein Design
Tags: Developability Macrocyclic Proteins Small Molecules
Key Capabilities
- Unifies structure prediction and binder design in a single all-atom diffusion framework.
- Supports protein, peptide, nanobody, and cyclic peptide binders targeting proteins, nucleic acids, or small molecules.
- Enables controllable generation of diverse and designable binders through architecture-level conditioning and tunable noise schedules.
- Includes a downstream pipeline for inverse folding, affinity estimation, and physics-based filtering to identify top candidates for experimental validation.
- Validated experimentally across 26 targets, achieving nanomolar-affinity binders in most tested protein and peptide campaigns.
Runtime Statistics
| Metric | Value |
|---|---|
| runtime_mean | 4161 |
| runtime_median | 1324 |
| runtime_std | 8140 |
| runtime_90th_percentile | 10272 |
| runtime_max | 69296 |
Similar Tools
- AfCycDesign
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Ready to submit your job?
Review your configuration, then confirm the estimated credit cost before you run the job. Note that credit estimates are not guaranteed and runtime can vary depending on inputs and settings.
Estimated Credits: 0.001178
Invite-only, limited-time access. Please contact ztang@getantibody.com.
Invite-only, limited-time access. Please contact ztang@getantibody.com.