MUSCLE v5 MSA Generation
Rapidly generate high-quality multiple sequence alignments for protein sequences.
MUSCLE v5 is a novel multiple sequence alignment algorithm that generates an ensemble of high-accuracy MSAs with diverse biases. It achieves this by perturbing a hidden Markov model (HMM) and permuting the guide tree used in the progressive alignment.
Estimated resource cost: 0.000248
Categories: Evolution & Phylogenetics, Sequence Analysis & Annotation
Tags: Multiple Sequence Alignment Proteins
Key Capabilities
- Generates high-quality multiple sequence alignments for biological sequences, with demonstrated accuracy improvements over popular tools like Clustal-Omega and MAFFT.
- Constructs an ensemble of MSA replicates by introducing controlled variations in the HMM parameters and guide tree, enabling assessment of alignment uncertainty and bias.
- Designed to scale to alignments of tens of thousands of sequences using a divide-and-conquer strategy.
Runtime Statistics
| Metric | Value |
|---|---|
| runtime_mean | 143 |
| runtime_median | 4 |
| runtime_std | 840 |
| runtime_90th_percentile | 73 |
| runtime_max | 9050 |
Similar Tools
- MAFFT MSA Generation
- mmseqs2 MSA Generation
- ANARCI
- ANARCII
Ready to submit your job?
Review your configuration, then confirm the estimated credit cost before you run the job. Note that credit estimates are not guaranteed and runtime can vary depending on inputs and settings.
Estimated Credits: 0.000248
Invite-only, limited-time access. Please contact ztang@getantibody.com.
Invite-only, limited-time access. Please contact ztang@getantibody.com.