QEPPI
Screen and evaluate early-stage PPI-targeting compounds with a tailored drug-likeness index.
QEPPI is a specialized index for early-stage screening of compounds targeting protein-protein interactions (PPIs). It extends the concept of drug-likeness quantification beyond traditional methods like QED, offering a continuous, adjustable metric tailored for PPI-targeting drug discovery. Built from experimental PPI data rather than FDA-approved drugs, QEPPI is ideal for identifying seed compounds that may evolve into PPI inhibitors or stabilizers, supporting both virtual screening and generative modeling applications.
Estimated resource cost: 0.000062
Categories: Ligand/Drug Design & Screening
Tags: Small Molecules Virtual Screening
Key Capabilities
- Quantitatively assess drug-likeness specifically for PPI-targeting compounds.
- Designed for early-stage discovery using experimental datasets like iPPI-DB.
- Outperforms traditional indices like QED and RO4 for PPI compounds.
- Provides an adjustable threshold to balance sensitivity and specificity.
Runtime Statistics
| Metric | Value |
|---|---|
| runtime_mean | 5 |
| runtime_median | 3 |
| runtime_std | 21 |
| runtime_90th_percentile | 4 |
| runtime_max | 201 |
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Ready to submit your job?
Review your configuration, then confirm the estimated credit cost before you run the job. Note that credit estimates are not guaranteed and runtime can vary depending on inputs and settings.
Estimated Credits: 0.000062
Invite-only, limited-time access. Please contact ztang@getantibody.com.
Invite-only, limited-time access. Please contact ztang@getantibody.com.